Article
LC-MS candidate reference methods for the harmonisation of parathyroid hormone (PTH) measurement: a review of recent developments and future considerations.
Clinical chemistry and laboratory medicine - 1 Sept 2014
Couchman Lewis, Taylor David R, Krastins Bryan, Lopez Mary F, Moniz Cajetan F
Abstract excerpt
The analysis of intact parathyroid hormone (PTH) (PTH1-84) is useful in the diagnosis of hyper- and hypocalcaemia, hyperparathyroidism, and in the prevention of bone mineral disorders in renal patients. The analysis is complicated by the presence of PTH fragments, which may accumulate in renal failure and cross-react in immunoassays, including the most recent third-generation immunoassays. Large variability...
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