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Article

Mitochondrial–nuclear genome interactions in non-alcoholic fatty liver disease in mice

24 Apr 2014

Abstract excerpt

NAFLD (non-alcoholic fatty liver disease) involves significant changes in liver metabolism characterized by oxidative stress, lipid accumulation and fibrogenesis. Mitochondrial dysfunction and bioenergetic defects also contribute to NAFLD. In the present study, we examined whether differences in mtDNA influence NAFLD. To determine the role of mitochondrial and nuclear genomes in NAFLD, MNX (mitochondrial-nuclear...

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PMID: 24758559
DOI: 10.1042/bj20131433

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