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Article

Analysis of Parkinson's disease brain-derived DNA for alpha-synuclein coding somatic mutations.

Movement disorders : official journal of the Movement Disorder Society - 1 Jul 2014

Proukakis Christos, Shoaee Maryiam, Morris James, Brier Timothy, Kara Eleanna, Sheerin Una-Marie, Charlesworth Gavin, Tolosa Eduardo, Houlden Henry, Wood Nicholas W, Schapira Anthony H

Abstract excerpt

BACKGROUND: Although alpha-synuclein (SNCA) is crucial to the pathogenesis of Parkinson's disease (PD) and dementia with Lewy bodies (DLB), mutations in the gene appear to be rare. We have recently hypothesized that somatic mutations in early development could contribute to PD. METHODS: Expanding on our recent negative small study, we used high-resolution melting (HRM) analysis to screen SNCA coding exons for...

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Source

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Identifiers

PMID: 24752924
DOI: 10.1002/mds.25883
PMCID: PMC4190821

Genes

SNCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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