Article
Peripheral blood hematopoietic stem and progenitor cell frequency is unchanged in patients with alpha-1-antitrypsin deficiency.
International journal of hematology - 1 Jun 2014
de Kruijf Evert-Jan F M, Alkemade Gonnie M, van Os Ronald, Fibbe Willem E, van Pel Melissa
Abstract excerpt
Granulocyte-colony-stimulating factor (G-CSF)-induced hematopoietic stem and progenitor cell (HSPC) mobilization is associated with the release of neutrophil-derived proteases. Previously, we have shown that alpha-1-antitrypsin (AAT) inhibits these proteases in mice, resulting in inhibition of HSPC mobilization. Here, we studied the relationship between AAT and HSPC in steady state and cytokine-induced...
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