Article
Association of a polymorphism in a gene encoding a urate transporter with CKD progression.
Clinical journal of the American Society of Nephrology : CJASN - 6 Jun 2014
Testa Alessandra, Mallamaci Francesca, Spoto Belinda, Pisano Anna, Sanguedolce Maria Cristina, Tripepi Giovanni, Leonardis Daniela, Zoccali Carmine
Abstract excerpt
BACKGROUND AND OBJECTIVES: Hyperuricemia predicts a high risk for CKD progression but there is no large clinical trial in humans indicating that this relationship is causal in nature. The rs734553 single-nucleotide polymorphism (SNP) of the GLUT9 urate transporter gene was strongly associated with uric acid (UA) levels in a large meta-analysis. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This prospective study...
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