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Article

Orchestrated increase of dopamine and PARK mRNAs but not miR-133b in dopamine neurons in Parkinson's disease.

Neurobiology of aging - 1 Oct 2014

Schlaudraff Falk, Gründemann Jan, Fauler Michael, Dragicevic Elena, Hardy John, Liss Birgit

Abstract excerpt

Progressive loss of substantia nigra dopamine neurons (SN DA) is a hallmark of aging and of Parkinson's disease (PD). Mutations in PARK genes cause familial PD forms. Increased expression of alpha-synuclein (PARK4) is a disease-triggering event in familial PD and also observed in SN DA neurons in sporadic PD but related transcriptional changes are unknown. With optimized single-cell quantitative real-time...

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Identifiers

PMID: 24742361
DOI: 10.1016/j.neurobiolaging.2014.03.016
PMCID: PMC4099518

Genes

UCHL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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