Article
Quantitative trait loci (QTL) study identifies novel genomic regions associated to Chiari-like malformation in Griffon Bruxellois dogs.
PloS one - 1 Jan 2014
Lemay Philippe, Knowler Susan P, Bouasker Samir, Nédélec Yohann, Platt Simon, Freeman Courtenay, Child Georgina, Barreiro Luis B, Rouleau Guy A, Rusbridge Clare, Kibar Zoha
Abstract excerpt
Chiari-like malformation (CM) is a developmental abnormality of the craniocervical junction that is common in the Griffon Bruxellois (GB) breed with an estimated prevalence of 65%. This disease is characterized by overcrowding of the neural parenchyma at the craniocervical junction and disturbance of cerebrospinal fluid (CSF) flow. The most common clinical sign is pain either as a direct consequence of CM or...
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