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Article

A genome-wide association study identifies candidate loci associated to syringomyelia secondary to Chiari-like malformation in Cavalier King Charles Spaniels.

BMC genetics - 22 Mar 2018

Ancot Frédéric, Lemay Philippe, Knowler Susan P, Kennedy Karen, Griffiths Sandra, Cherubini Giunio Bruto, Sykes Jane, Mandigers Paul J J, Rouleau Guy A, Rusbridge Clare, Kibar Zoha

Abstract excerpt

BACKGROUND: Syringomyelia (SM) is a common condition affecting brachycephalic toy breed dogs and is characterized by the development of fluid-filled cavities within the spinal cord. It is often concurrent with a complex developmental malformation of the skull and craniocervical vertebrae called Chiari-like malformation (CM) characterized by a conformational change and overcrowding of the brain and cervical spinal...

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Identifiers

PMID: 29566674
DOI: 10.1186/s12863-018-0605-z
PMCID: PMC5865342

Genes

PCDH17
ZWINT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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