Article
A role for lactate dehydrogenases in the survival of Neisseria gonorrhoeae in human polymorphonuclear leukocytes and cervical epithelial cells.
The Journal of infectious diseases - 15 Oct 2014
Atack John M, Ibranovic Ines, Ong Cheryl-Lynn Y, Djoko Karrera Y, Chen Nathan H, Vanden Hoven Rachel, Jennings Michael P, Edwards Jennifer L, McEwan Alastair G
Abstract excerpt
Lactate is an abundant metabolite, produced by host tissues and commensal organisms, and it represents an important potential carbon source for bacterial pathogens. In the case of Neisseria spp., the importance of the lactate permease in colonization of the host has been demonstrated, but there have been few studies of lactate metabolism in pathogenic Neisseria in the postgenomic era. We describe herein the...
Topics
- Bacterial Proteins
- Cervix Uteri
- DNA, Bacterial
- Epithelial Cells
- Female
- Gene Expression Regulation, Bacterial
- Gene Expression Regulation, Enzymologic
- Humans
- Lactate Dehydrogenases
- Mutation
- Neisseria gonorrhoeae
- Neutrophils