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Article

Antileukemic activity and mechanism of drug resistance to the marine Salinispora tropica proteasome inhibitor salinosporamide A (Marizomib).

Molecular pharmacology - 1 Jul 2014

Niewerth Denise, Jansen Gerrit, Riethoff Lesley F V, van Meerloo Johan, Kale Andrew J, Moore Bradley S, Assaraf Yehuda G, Anderl Janet L, Zweegman Sonja, Kaspers Gertjan J L, Cloos Jacqueline

Abstract excerpt

Salinosporamide A (NPI-0052, marizomib) is a naturally occurring proteasome inhibitor derived from the marine actinobacterium Salinispora tropica, and represents a promising clinical agent in the treatment of hematologic malignancies. Recently, these actinobacteria were shown to harbor self-resis...

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Identifiers

PMID: 24737138
DOI: 10.1124/mol.114.092114
PMCID: PMC4054006

Genes

PSMB5

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24737138-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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