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Article

Different mutants of PSMB5 confer varying bortezomib resistance in T lymphoblastic lymphoma/leukemia cells derived from the Jurkat cell line.

Experimental hematology - 1 Jul 2009

Lü Shuqing, Yang Jianmin, Chen Zhilong, Gong Shenglan, Zhou Hong, Xu Xiaoqian, Wang Jianmin

Abstract excerpt

OBJECTIVE: To investigate the relationship between bortezomib resistance and mutations in the proteasome beta5 subunit (PSMB5) gene. MATERIALS AND METHODS: Various bortezomib-resistant lymphoblastic lymphoma/leukemia lines were established by repeated cycles of bortezomib selection. Mutations were detected by sequencing the complementary DNA of the PSMB5 gene. Mutated clones were selected by limited dilution and...

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Source

Identifiers

PMID: 19426847
DOI: 10.1016/j.exphem.2009.04.001

Genes

PSMB5

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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