Article
Clinical and biochemical profiles suggest fibromuscular dysplasia is a systemic disease with altered TGF-β expression and connective tissue features.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Aug 2014
Ganesh Santhi K, Morissette Rachel, Xu Zhi, Schoenhoff Florian, Griswold Benjamin F, Yang Jiandong, Tong Lan, Yang Min-Lee, Hunker Kristina, Sloper Leslie, Kuo Shinie, Raza Rafi, Milewicz Dianna M, Francomano Clair A, Dietz Harry C, Van Eyk Jennifer, McDonnell Nazli B
Abstract excerpt
Fibromuscular dysplasia (FMD) is a rare, nonatherosclerotic arterial disease for which the molecular basis is unknown. We comprehensively studied 47 subjects with FMD, including physical examination, spine magnetic resonance imaging, bone densitometry, and brain magnetic resonance angiography. Inflammatory biomarkers in plasma and transforming growth factor β (TGF-β) cytokines in patient-derived dermal...
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