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Article

The combination of MK-5172, peginterferon, and ribavirin is effective in treatment-naive patients with hepatitis C virus genotype 1 infection without cirrhosis.

Gastroenterology - 1 Aug 2014

Manns Michael P, Vierling John M, Bacon Bruce R, Bruno Savino, Shibolet Oren, Baruch Yaacov, Marcellin Patrick, Caro Luzelena, Howe Anita Y M, Fandozzi Christine, Gress Jacqueline, Gilbert Christopher L, Shaw Peter M, Cooreman Michael P, Robertson Michael N, Hwang Peggy, Dutko Frank J, Wahl Janice, Mobashery Niloufar

Abstract excerpt

BACKGROUND & AIMS: MK-5172 is an inhibitor of the hepatitis C virus (HCV) nonstructural protein 3/4A protease; MK-5172 is taken once daily and has a higher potency and barrier to resistance than licensed protease inhibitors. We investigated the efficacy and tolerability of MK-5172 with peginterferon and ribavirin (PR) in treatment-naive patients with chronic HCV genotype 1 infection without cirrhosis. METHODS: We...

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Identifiers

PMID: 24727022
DOI: 10.1053/j.gastro.2014.04.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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