Safety and efficacy of a fixed-dose combination regimen of grazoprevir, ruzasvir, and uprifosbuvir with or without ribavirin in participants with and without cirrhosis with chronic hepatitis C virus genotype 1, 2, or 3 infection (C-CREST-1 and C-CREST-2, part B): two randomised, phase 2, open-label trials.

doi:10.1016/S2468-1253(17)30163-2

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Safety and efficacy of a fixed-dose combination regimen of grazoprevir, ruzasvir, and uprifosbuvir with or without ribavirin in participants with and without cirrhosis with chronic hepatitis C virus genotype 1, 2, or 3 infection (C-CREST-1 and C-CREST-2, part B): two randomised, phase 2, open-label trials.

The lancet. Gastroenterology & hepatology - 1 Nov 2017

Lawitz Eric, Buti Maria, Vierling John M, Almasio Piero L, Bruno Savino, Ruane Peter J, Hassanein Tarek I, Muellhaupt Beat, Pearlman Brian, Jancoriene Ligita, Gao Wei, Huang Hsueh-Cheng, Shepherd Aimee, Tannenbaum Brynne, Fernsler Doreen, Li Jerry J, Grandhi Anjana, Liu Hong, Su Feng-Hsiu, Wan Shuyan, Dutko Frank J, Nguyen Bach-Yen T, Wahl Janice, Robertson Michael N, Barr Eliav, Yeh Wendy W, Plank Rebeca M, Butterton Joan R, Yoshida Eric M

Abstract excerpt

BACKGROUND: There is a need for hepatitis C virus (HCV) therapies with excellent efficacy across genotypes and in diverse populations. Part A of the C-CREST-1 and C-CREST-2 trials led to the selection of a three-drug regimen of grazoprevir (MK-5172; an HCV NS3/4A protease inhibitor; 100 mg/day) plus ruzasvir (MK-8408; an NS5A inhibitor; 60 mg/day) plus uprifosbuvir (MK-3682; an HCV NS5B polymerase inhibitor; 450...

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PMID: 28802814
DOI: 10.1016/S2468-1253(17)30163-2

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