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Mitochondrial toxicity of antiepileptic drugs and their tolerability in mitochondrial disorders

7 Dec 2011

Abstract excerpt

INTRODUCTION: Epilepsy is a frequent CNS manifestation of mitochondrial disorders (MIDs). At present, patients with MID-related epilepsy are largely treated in the same way as any other epilepsy sufferer. The problem with this approach is that some antiepileptic drugs (AEDs) are mitochondrial toxic and care is, therefore, needed when administering these AEDs to patients with MIDs. AREAS COVERED: This review...

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PMID: 22149023
DOI: 10.1517/17425255.2012.644535

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