Article
5-lipoxygenase-dependent recruitment of neutrophils and macrophages by eotaxin-stimulated murine eosinophils.
Mediators of inflammation - 1 Jan 2014
Luz Ricardo Alves, Xavier-Elsas Pedro, de Luca Bianca, Masid-de-Brito Daniela, Cauduro Priscila Soares, Arcanjo Luiz Carlos Gondar, dos Santos Ana Carolina Cordeiro Faria, de Oliveira Ivi Cristina Maria, Gaspar-Elsas Maria Ignez Capella
Abstract excerpt
The roles of eosinophils in antimicrobial defense remain incompletely understood. In ovalbumin-sensitized mice, eosinophils are selectively recruited to the peritoneal cavity by antigen, eotaxin, or leukotriene(LT)B4, a 5-lipoxygenase (5-LO) metabolite. 5-LO blockade prevents responses to both antigen and eotaxin. We examined responses to eotaxin in the absence of sensitization and their dependence on 5-LO....
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