Article
miR-10a and miR-10b target the 3'-untranslated region of TBX5 to repress its expression.
Pediatric cardiology - 1 Aug 2014
Wang Feng, Yang Xue-Yan, Zhao Jian-Yuan, Yu Li-Wei, Zhang Ping, Duan Wen-Yuan, Chong Mei, Gui Yong-Hao
Abstract excerpt
As a well-known transcription factor, TBX5 is involved in embryonic cardiac development. Although TBX5 functions in a dose-dependent manner, the posttranscriptional regulation of human TBX5 is poorly understood. Thus, this study aimed to identify microRNAs that modulate TBX5 expression. Luciferas...
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