Article
IL10 low-frequency variants in Behçet's disease patients.
International journal of rheumatic diseases - 1 May 2017
Matos Mafalda, Xavier Joana M, Abrantes Patrícia, Sousa Inês, Rei Nádia, Davatchi Fereydoun, Shahram Farhad, Jesus Gorete, Barcelos Filipe, Vedes Joana, Salgado Manuel, Abdollahi Bahar Sadeghi, Nadji Abdolhadi, Moraes-Fontes Maria Francisca, Shafiee Niloofar Mojarad, Ghaderibarmi Fahmida, Vaz Patto José, Crespo Jorge, Oliveira Sofia A
Abstract excerpt
AIM: To explain the missing heritability after the genome-wide association studies era, sequencing studies allow the identification of low-frequency variants with a stronger effect on disease risk. Common variants in the interleukin 10 gene (IL10) have been consistently associated with Behçet's disease (BD) and the goal of this study is to investigate the role of low-frequency IL10 variants in BD susceptibility....
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