Genome sequencing of disease and carriage isolates of nontypeable <i>Haemophilus influenzae</i> identifies discrete population structure

Abstract excerpt

One of the main hurdles for the development of an effective and broadly protective vaccine against nonencapsulated isolates of Haemophilus influenzae (NTHi) lies in the genetic diversity of the species, which renders extremely difficult the identification of cross-protective candidate antigens. To assess whether a population structure of NTHi could be defined, we performed genome sequencing of a collection of...

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