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Article

Neuron-derived neurotrophic factor functions as a novel modulator that enhances endothelial cell function and revascularization processes.

The Journal of biological chemistry - 16 May 2014

Ohashi Koji, Enomoto Takashi, Joki Yusuke, Shibata Rei, Ogura Yasuhiro, Kataoka Yoshiyuki, Shimizu Yuuki, Kambara Takahiro, Uemura Yusuke, Yuasa Daisuke, Matsuo Kazuhiro, Hayakawa Satoko, Hiramatsu-Ito Mizuho, Murohara Toyoaki, Ouchi Noriyuki

Abstract excerpt

Strategies to stimulate revascularization are valuable for cardiovascular diseases. Here we identify neuron-derived neurotrophic factor (NDNF)/epidermacan as a secreted molecule that is up-regulated in endothelial cells in ischemic limbs of mice. NDNF was secreted from cultured human endothelial cells, and its secretion was stimulated by hypoxia. NDNF promoted endothelial cell network formation and survival in...

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Source

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Identifiers

PMID: 24706764
DOI: 10.1074/jbc.M114.555789
PMCID: PMC4022881

Genes

NDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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