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Structure and function of RNase AS, a polyadenylate-specific exoribonuclease affecting mycobacterial virulence in vivo.

Structure (London, England : 1993) - 6 May 2014

Romano Maria, van de Weerd Robert, Brouwer Femke C C, Roviello Giovanni N, Lacroix Ruben, Sparrius Marion, van den Brink-van Stempvoort Gunny, Maaskant Janneke J, van der Sar Astrid M, Appelmelk Ben J, Geurtsen Jeroen J, Berisio Rita

Abstract excerpt

The cell-envelope of Mycobacterium tuberculosis plays a key role in bacterial virulence and antibiotic resistance. Little is known about the molecular mechanisms of regulation of cell-envelope formation. Here, we elucidate functional and structural properties of RNase AS, which modulates M. tuberculosis cell-envelope properties and strongly impacts bacterial virulence in vivo. The structure of RNase AS reveals a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 24704253
DOI: 10.1016/j.str.2014.01.014

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