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Article

The prognostic impact of minimal residual disease in patients with chronic lymphocytic leukemia requiring first-line therapy.

Haematologica - 1 May 2014

Santacruz Rodrigo, Villamor Neus, Aymerich Marta, Martínez-Trillos Alejandra, López Cristina, Navarro Alba, Rozman María, Beà Sílvia, Royo Cristina, Cazorla Maite, Colomer Dolors, Giné Eva, Pinyol Magda, Puente Xose S, López-Otín Carlos, Campo Elías, López-Guillermo Armando, Delgado Julio

Abstract excerpt

A proportion of patients with chronic lymphocytic leukemia achieve a minimal residual disease negative status after therapy. We retrospectively evaluated the impact of minimal residual disease on the outcome of 255 consecutive patients receiving any front-line therapy in the context of a detailed prognostic evaluation, including assessment of IGHV, TP53, NOTCH1 and SF3B1 mutations. The median follow-up was 73...

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Identifiers

PMID: 24700492
DOI: 10.3324/haematol.2013.099796
PMCID: PMC4008107

Genes

NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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