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The polyphenol (−)-epicatechin gallate disrupts the secretion of virulence-related proteins by Staphylococcus aureus

7 Dec 2007

Abstract excerpt

AIM: (-)-epicatechin gallate (ECg) modifies the morphology, cell wall architecture and beta-lactam antibiotic susceptibility of Staphylococcus aureus. As these effects result primarily from intercalation into the bacterial cytoplasmic membrane, the capacity of ECg to modulate the secretion of two key staphylococcal virulence factors, coagulase and alpha-toxin, was examined. METHODS AND RESULTS: Bioassays were...

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PMID: 18069979
DOI: 10.1111/j.1472-765x.2007.02296.x

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