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Article

A naturally occurring canine model of syndromic congenital microphthalmia.

G3 (Bethesda, Md.) - 5 Jun 2024

Murgiano Leonardo, Banjeree Esha, O'Connor Cynthia, Miyadera Keiko, Werner Petra, Niggel Jessica K, Aguirre Gustavo D, Casal Margret L

Abstract excerpt

In humans, the prevalence of congenital microphthalmia is estimated to be 0.2-3.0 for every 10,000 individuals, with nonocular involvement reported in ∼80% of cases. Inherited eye diseases have been widely and descriptively characterized in dogs, and canine models of ocular diseases have played an essential role in unraveling the pathophysiology and development of new therapies. A naturally occurring canine model...

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Identifiers

PMID: 38682429
DOI: 10.1093/g3journal/jkae067
PMCID: PMC11152080

Genes

DNAJC21
DNAJC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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