Article
Both the C1 domain and a basic amino acid cluster at the C-terminus are important for the neurite and branch induction ability of DGKβ.
Biochemical and biophysical research communications - 25 Apr 2014
Kano Takuya, Kouzuki Takeshi, Mizuno Satoru, Ueda Shuji, Yamanoue Minoru, Sakane Fumio, Saito Naoaki, Shirai Yasuhito
Abstract excerpt
We previously reported that diacylglycerol kinase β (DGKβ) induces neurites and branches, contributing to higher brain function including emotion and memories. However, the detailed molecular mechanism of DGKβ function remains unknown. Therefore, we constructed various mutants of DGKβ and compared their enzyme activity, intracellular localization, and ability to induce neurites and branching in SH-SY5Y cells....
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