Article
The interaction of a single-nucleotide polymorphism with age on response to interferon-α and ribavirin therapy in female patients with hepatitis C infection.
Journal of medical virology - 1 Jul 2014
Nishino Jo, Sugiyama Masaya, Nishida Nao, Tokunaga Katsushi, Mizokami Masashi, Mano Shuhei
Abstract excerpt
Older female patients exhibit a poor response to the current standard treatment for hepatitis C, interferon-α, and ribavirin (PEG-IFN-α/RBV). In this study, we reported that the combination of age and the genotype of a novel SNP can predict response to standard treatment (P = 7.31 × 10(-8)). The model incorporating genotype of the novel SNP, rs1287948, predicts response more accurately (AUC = 0.934; 95%...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.