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Article

Serum bilirubin affects graft outcomes through UDP-glucuronosyltransferase sequence variation in kidney transplantation.

PloS one - 1 Jan 2014

Lee Jung Pyo, Kim Do Hyoung, Yang Seung Hee, Hwang Jin Ho, An Jung Nam, Min Sang Il, Ha Jongwon, Oh Yun Kyu, Kim Yon Su, Lim Chun Soo

Abstract excerpt

BACKGROUND: Oxidative stress is a major mediator of adverse outcome after kidney transplantation. Bilirubin is produced by heme oxygenase-1 (HO-1), catalyzed by UDP-glucuronosyltransferase (UGT1A1), and has potential as an antioxidant. In this study, we investigated the effects of HO-1 and UGT1A1 sequence variations on kidney allograft outcomes. METHODS: Clinical data were collected from 429 Korean recipients who...

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Identifiers

PMID: 24690955
DOI: 10.1371/journal.pone.0093633
PMCID: PMC3972238

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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