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Article

Human amylase gene copy number variation as a determinant of metabolic state

4 Jul 2018

Abstract excerpt

INTRODUCTION: Humans have multiple genes encoding amylase that are broadly divided into salivary (AMY1) and pancreatic (AMY2) genes. They exhibit some of the greatest copy numbers of any human gene, an expansion possibly driven by increased dietary starch intake. Within the population, amylase gene copy number is highly variable and there is evidence of an inverse association between AMY1 copy number and BMI....

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PMID: 30063422
DOI: 10.1080/17446651.2018.1499466

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