Article
Fractionated radiotherapy is the main stimulus for the induction of cell death and of Hsp70 release of p53 mutated glioblastoma cell lines.
Radiation oncology (London, England) - 30 Mar 2014
Rubner Yvonne, Muth Carolin, Strnad Annedore, Derer Anja, Sieber Renate, Buslei Rolf, Frey Benjamin, Fietkau Rainer, Gaipl Udo S
Abstract excerpt
BACKGROUND: Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults. Despite a multimodal therapy consisting of resection followed by fractionated radiotherapy (RT) combined with the chemotherapeutic agent (CT) temozolomide (TMZ), its recurrence is almost inevitable. Since the immune system is capable of eliminating small tumor masses, a therapy should also aim to stimulate anti-tumor...
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