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Article

Combined folate gene MTHFD and TC polymorphisms as maternal risk factors for Down syndrome in China.

Genetics and molecular research : GMR - 17 Mar 2014

Liao Y P, Zhang D, Zhou W, Meng F M, Bao M S, Xiang P, Liu C Q

Abstract excerpt

We examined whether polymorphisms in the methylenetetrahydrofolate dehydrogenase (MTHFD) and transcobalamin (TC) genes, which are involved in folate metabolism, affect maternal risk for Down syndrome. We investigated 76 Down syndrome mothers and 115 control mothers from Bengbu, China. Genomic DNA was isolated from the peripheral lymphocytes. Polymerase chain reaction and restriction fragment length polymorphism...

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Source

Identifiers

PMID: 24668664
DOI: 10.4238/2014.March.17.4

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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