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Article

GLP-1-mediated gene therapy approaches for diabetes treatment

1 Jan 2014

Abstract excerpt

Glucagon-like peptide (GLP)-1 is an incretin hormone with several antidiabetic functions including stimulation of glucose-dependent insulin secretion, increase in insulin gene expression and beta-cell survival. Despite the initial technical difficulties and profound inefficiency of direct gene transfer into the pancreas that seriously restricted in vivo gene transfer experiments with GLP-1, recent exploitation of...

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PMID: 24666581
DOI: 10.1017/erm.2014.7

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