Article
Study of transforming growth factor-β1 gene, mRNA, and protein in Japanese renal transplant recipients.
Transplantation proceedings - 1 Jan 2014
Saigo K, Akutsu N, Maruyama M, Otsuki K, Hasegawa M, Aoyama H, Matsumoto I, Asano T, Kenmochi T
Abstract excerpt
BACKGROUND: Transforming growth factor (TGF)-β1 may contribute to chronic allograft nephropathy and graft loss; however, the exact molecular mechanism remains unclear. Therefore, we assess the relationship between TGF-β1 gene polymorphisms, expression, and development of allograft nephropathy. METHODS: We studied 135 renal transplant recipients at our hospital. TGF-β1 gene polymorphisms (codons 10 and 25) were...
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