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Article

Decreased decorin expression in the tumor microenvironment

17 Mar 2014

Abstract excerpt

Decorin is a small leucine-rich proteoglycan, synthesized and deposited by fibroblasts in the stroma where it binds to collagen I. It sequesters several growth factors and antagonizes numerous members of the receptor tyrosine kinase family. In experimental murine systems, it acted as a potent tumor suppressor. Examining the Human Protein Atlas online database of immunostained tissue samples we have surveyed...

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PMID: 24634138
DOI: 10.1002/cam4.231

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