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Article

Deficiency of the decorin core protein in the variant form of Ehlers-Danlos syndrome with chronic skin ulcer.

Journal of dermatological science - 1 Oct 2001

Wu J, Utani A, Endo H, Shinkai H

Abstract excerpt

Decorin belongs to a family of small leucine-rich dermatan sulfate proteoglycans that are involved in the control of matrix organization and cell growth. Here, we described a patient whose skin glycosaminoglycans showed extremely decreased amount of dermatan sulfate compared with a normal control skin. This patient presented clinical features of Ehlers-Danlos syndrome with a chronic skin ulcer. Western blotting...

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Identifiers

PMID: 11532373
DOI: 10.1016/s0923-1811(01)00102-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Deficiency of the decorin core protein in the variant form of Ehlers-Danlos syndrome with chronic skin ulcer.PMID 11532373Read ↗

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Decorin counteracts disease progression in mice with recessive dystrophic epidermolysis bullosaSemantic proximity Read ↗

Genetic heterogeneity and clinical variability in musculocontractural Ehlers-Danlos syndrome caused by impaired dermatan sulfate biosynthesis.Semantic proximity Read ↗

Role of Decorin in the Lens and Ocular DiseasesSemantic proximity Read ↗

Phenotypic effects of biglycan deficiency are linked to collagen fibril abnormalities, are synergized by decorin deficiency, and mimic Ehlers-Danlos-like changes in bone and other connective tissues.Semantic proximity Read ↗

Transcriptome analysis of skin fibroblasts with dominant negative COL3A1 mutations provides molecular insights into the etiopathology of vascular Ehlers-Danlos syndrome.Semantic proximity Read ↗

The Human Decorin Gene: Intron-Exon Organization, Discovery of Two Alternatively Spliced Exons in the 5′ Untranslated Region, and Mapping of the Gene to Chromosome 12q23Semantic proximity Read ↗

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