Article
Septins promote F-actin ring formation by crosslinking actin filaments into curved bundles.
Nature cell biology - 1 Apr 2014
Mavrakis Manos, Azou-Gros Yannick, Tsai Feng-Ching, Alvarado José, Bertin Aurélie, Iv Francois, Kress Alla, Brasselet Sophie, Koenderink Gijsje H, Lecuit Thomas
Abstract excerpt
Animal cell cytokinesis requires a contractile ring of crosslinked actin filaments and myosin motors. How contractile rings form and are stabilized in dividing cells remains unclear. We address this problem by focusing on septins, highly conserved proteins in eukaryotes whose precise contribution to cytokinesis remains elusive. We use the cleavage of the Drosophila melanogaster embryo as a model system, where...
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