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Article

Elevated circulating Sclerostin concentrations in individuals with high bone mass, with and without LRP5 mutations.

The Journal of clinical endocrinology and metabolism - 1 Aug 2014

Gregson Celia L, Poole Kenneth E S, McCloskey Eugene V, Duncan Emma L, Rittweger Jörn, Fraser William D, Smith George Davey, Tobias Jonathan H

Abstract excerpt

CONTEXT: The role and importance of circulating sclerostin is poorly understood. High bone mass (HBM) caused by activating LRP5 mutations has been reported to be associated with increased plasma sclerostin concentrations; whether the same applies to HBM due to other causes is unknown. OBJECTIVE: Our objective was to determine circulating sclerostin concentrations in HBM. DESIGN AND PARTICIPANTS: In this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24606091
DOI: 10.1210/jc.2013-3958
PMCID: PMC4207929

Genes

HBM
LRP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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