Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genomic Profiling of Metastatic Uveal Melanoma and Clinical Results of a Phase I Study of the Protein Kinase C Inhibitor AEB071

6 Feb 2020

Abstract excerpt

Abstract Up to 50% of patients with uveal melanoma (UM) develop metastatic disease, for which there is no effective systemic treatment. This study aimed to evaluate the safety and efficacy of the orally available protein kinase C inhibitor, AEB071, in patients with metastatic UM, and to perform genomic profiling of metastatic tumor samples, with the aim to propose combination therapies. Patients with metastatic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cutaneous Melanoma Detection and Management
Share to Nonmelanoma Skin Cancer Studies
Share to Ocular Oncology and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32029634
DOI: 10.1158/1535-7163.mct-19-0098

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genomic Profiling of Metastatic Uveal Melanoma and Clinical Results of a Phase I Study of the Protein Kinase C Inhibitor AEB071PMID 32029634Read ↗

Emerging therapeutic strategies for metastatic uveal melanoma: Targeting driver mutations.Semantic proximity Read ↗

Genomic, prognostic, and cell-signaling advances in uveal melanoma.Semantic proximity Read ↗

Targeting GNAQ/11 through PKC inhibition in uveal melanoma.Semantic proximity Read ↗

Protein Kinase C Inhibitor AEB071 Targets Ocular Melanoma Harboring GNAQ Mutations via Effects on the PKC/Erk1/2 and PKC/NF-κB PathwaysSemantic proximity Read ↗

Uveal melanoma: epidemiology, etiology, and treatment of primary diseaseSemantic proximity Read ↗

Protein kinase inhibitor responses in uveal melanoma reflects a diminished dependency on PKC-MAPK signaling.Semantic proximity Read ↗

Uveal Melanoma: Molecular and Genetic Mechanisms of Development and Therapeutic ApproachesSemantic proximity Read ↗

[Uveal Melanoma: Molecular and Genetic Mechanisms of Development and Therapeutic Approaches].Semantic proximity Read ↗

Molecular profiling of primary uveal melanoma: results of a Polish cohort.Semantic proximity Read ↗

Establishment of novel cell lines recapitulating the genetic landscape of uveal melanoma and preclinical validation of mTOR as a therapeutic targetSemantic proximity Read ↗

Uveal melanoma: progress in molecular biology and therapeuticsSemantic proximity Read ↗

Genetic landscape of uveal melanoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.