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Article

Identification of genetic variants associated with capecitabine-induced hand-foot syndrome through integration of patient and cell line genomic analyses.

Pharmacogenetics and genomics - 1 May 2014

Wheeler Heather E, González-Neira Anna, Pita Guillermo, de la Torre-Montero Julio-Cesar, Alonso Rosario, Lopez-Fernandez Luis A, Alba Emilio, Martín Miguel, Dolan M Eileen

Abstract excerpt

OBJECTIVE: A primary challenge in identifying replicable pharmacogenomic markers from clinical genomewide association study (GWAS) trials in oncology is the difficulty in performing a second large clinical trial with the same drugs and dosage regimen. We sought to overcome this challenge by incorporating GWAS results from cell-based studies using the same chemotherapy as a clinical cohort. METHODS: In this study,...

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Identifiers

PMID: 24595012
DOI: 10.1097/FPC.0000000000000037
PMCID: PMC4076106

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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