Article
The role of mutation rate variation and genetic diversity in the architecture of human disease.
PloS one - 1 Jan 2014
Eyre-Walker Ying Chen, Eyre-Walker Adam
Abstract excerpt
BACKGROUND: We have investigated the role that the mutation rate and the structure of genetic variation at a locus play in determining whether a gene is involved in disease. We predict that the mutation rate and its genetic diversity should be higher in genes associated with disease, unless all genes that could cause disease have already been identified. RESULTS: Consistent with our predictions we find that genes...
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