Article
A multi-site validation in India of the line probe assay for the rapid diagnosis of multi-drug resistant tuberculosis directly from sputum specimens.
PloS one - 1 Jan 2014
Raizada Neeraj, Sachdeva K S, Chauhan D S, Malhotra Bharti, Reddy Kishore, Dave P V, Mundade Yamuna, Patel Pranav, Ramachandran Ranjani, Das Ram, Solanki Rajesh, Wares Douglas Fraser, Sahu Suvanand, O'Brien Rick, Paramasivan C N, Dewan Puneet K
Abstract excerpt
UNLABELLED: Rifampicin (R) and isoniazid (H) are key first-line anti-tuberculosis drugs. Failure to detect resistance to these two drugs early results in treatment failure and poor clinical outcomes. The study purpose was to validate the use of the GenoType MTBDRplus line probe assay (LPA) to detect resistance to R and H in Mycobacterium tuberculosis strains directly from smear-positive sputum samples in India....
Topics
- Adult
- Female
- Humans
- India
- Isoniazid
- Male
- Microbial Sensitivity Tests
- Molecular Diagnostic Techniques
- Mutation
- Mycobacterium tuberculosis