Article
Fructose bisphosphate aldolase is involved in the control of RNA polymerase III-directed transcription.
Biochimica et biophysica acta - 1 Jun 2014
Cieśla Małgorzata, Mierzejewska Jolanta, Adamczyk Małgorzata, Farrants Ann-Kristin Östlund, Boguta Magdalena
Abstract excerpt
Yeast Fba1 (fructose 1,6-bisphosphate aldolase) is a glycolytic enzyme essential for viability. The overproduction of Fba1 enables overcoming of a severe growth defect caused by a missense mutation rpc128-1007 in a gene encoding the C128 protein, the second largest subunit of the RNA polymerase III complex. The suppression of the growth phenotype by Fba1 is accompanied by enhanced de novo tRNA transcription in...
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