Article
Causal relationship between the AHSG gene and BMD through fetuin-A and BMI: multiple mediation analysis.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA - 1 May 2014
Sritara C, Thakkinstian A, Ongphiphadhanakul B, Chailurkit L, Chanprasertyothin S, Ratanachaiwong W, Vathesatogkit P, Sritara P
Abstract excerpt
UNLABELLED: Using mediation analysis, a causal relationship between the AHSG gene and bone mineral density (BMD) through fetuin-A and body mass index (BMI) mediators was suggested. INTRODUCTION: Fetuin-A, a multifunctional protein of hepatic origin, is associated with bone mineral density. It is unclear if this association is causal. This study aimed at clarification of this issue. METHODS: A cross-sectional...
Topics
- Absorptiometry, Photon
- Adult
- Body Mass Index
- Bone Density
- Cross-Sectional Studies
- Female
- Genetic Association Studies
- Genotype
- Hip Joint
- Humans
- Lumbar Vertebrae
- Male