Article
New applications of disease genetics and pharmacogenetics to drug development.
Current opinion in pharmacology - 1 Feb 2014
Roses Allen D, Saunders Ann M, Lutz Michael W, Zhang Nanyin, Hariri Ahmad R, Asin Karen E, Crenshaw Donna G, Budur Kumar, Burns Daniel K, Brannan Stephen K
Abstract excerpt
TOMMORROW is a Phase III delay of onset clinical trial to determine whether low doses of pioglitazone, a molecule that induces mitochondrial doubling, delays the onset of MCI-AD in normal subjects treated with low dose compared to placebo. BOLD imaging studies in rodents and man were used to find the dose that increases oxygen consumption at central regions of the brain in higher proportion than activation of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.