Article
Strong association of variants around FOXE1 and orofacial clefting.
Journal of dental research - 1 Apr 2014
Ludwig K U, Böhmer A C, Rubini M, Mossey P A, Herms S, Nowak S, Reutter H, Alblas M A, Lippke B, Barth S, Paredes-Zenteno M, Muñoz-Jimenez S G, Ortiz-Lopez R, Kreusch T, Hemprich A, Martini M, Braumann B, Jäger A, Pötzsch B, Molloy A, Peterlin B, Hoffmann P, Nöthen M M, Rojas-Martinez A, Knapp M, Steegers-Theunissen R P, Mangold E
Abstract excerpt
Nonsyndromic orofacial clefting (nsOFC) is a common, complex congenital disorder. The most frequent forms are nonsyndromic cleft lip with or without cleft palate (nsCL/P) and nonsyndromic cleft palate only (nsCPO). Although they are generally considered distinct entities, a recent study has implicated a region around the FOXE1 gene in both nsCL/P and nsCPO. To investigate this hypothesis, we analyzed the 2 most...
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