Article
Whole-genome haplotyping using long reads and statistical methods.
Nature biotechnology - 1 Mar 2014
Kuleshov Volodymyr, Xie Dan, Chen Rui, Pushkarev Dmitry, Ma Zhihai, Blauwkamp Tim, Kertesz Michael, Snyder Michael
Abstract excerpt
The rapid growth of sequencing technologies has greatly contributed to our understanding of human genetics. Yet, despite this growth, mainstream technologies have not been fully able to resolve the diploid nature of the human genome. Here we describe statistically aided, long-read haplotyping (SLRH), a rapid, accurate method that uses a statistical algorithm to take advantage of the partially phased information...
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