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Article

miR-146a promotes the initiation and progression of melanoma by activating Notch signaling.

eLife - 18 Feb 2014

Forloni Matteo, Dogra Shaillay Kumar, Dong Yuying, Conte Darryl, Ou Jianhong, Zhu Lihua Julie, Deng April, Mahalingam Meera, Green Michael R, Wajapeyee Narendra

Abstract excerpt

Oncogenic mutations in BRAF and NRAS occur in 70% of melanomas. In this study, we identify a microRNA, miR-146a, that is highly upregulated by oncogenic BRAF and NRAS. Expression of miR-146a increases the ability of human melanoma cells to proliferate in culture and form tumors in mice, whereas knockdown of miR-146a has the opposite effects. We show these oncogenic activities are due to miR-146a targeting the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24550252
DOI: 10.7554/eLife.01460
PMCID: PMC3927633

Genes

BRAF
NRAS
NUMB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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