miR-146a Polymorphism (rs2910164) Predicts Colorectal Cancer Patients' Susceptibility to Liver Metastasis.

doi:10.1371/journal.pone.0165912

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Article

miR-146a Polymorphism (rs2910164) Predicts Colorectal Cancer Patients' Susceptibility to Liver Metastasis.

PloS one - 1 Jan 2016

Iguchi Tomohiro, Nambara Sho, Masuda Takaaki, Komatsu Hisateru, Ueda Masami, Kidogami Shinya, Ogawa Yushi, Hu Qingjiang, Sato Kuniaki, Saito Tomoko, Hirata Hidenari, Sakimura Shotaro, Uchi Ryutaro, Hayashi Naoki, Ito Shuhei, Eguchi Hidetoshi, Sugimachi Keishi, Maehara Yoshihiko, Mimori Koshi

Abstract excerpt

miR-146a plays important roles in cancer as it directly targets NUMB, an inhibitor of Notch signaling. miR-146a is reportedly regulated by a G>C polymorphism (SNP; rs2910164). This polymorphism affects various cancers, including colorectal cancer (CRC). However, the clinical significance of miR-146a polymorphism in CRC remains unclear. A total of 59 patients with CRC were divided into 2 groups: a CC/CG genotype...

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PMID: 27824903
DOI: 10.1371/journal.pone.0165912
PMCID: PMC5100922

Genes

NUMB
STAT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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