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Article

A genetic variant in vitamin B12 metabolic genes that reduces the risk of congenital heart disease in Han Chinese populations.

PloS one - 1 Jan 2014

Wang Jue, Zhao Jian-Yuan, Wang Feng, Peng Qian-Qian, Hou Jia, Sun Shu-Na, Gui Yong-Hao, Duan Wen-Yuan, Qiao Bin, Wang Hong-Yan

Abstract excerpt

BACKGROUND: Genome-wide association studies on components of the one-carbon metabolic pathway revealed that human vitamin B12 levels could be significantly influenced by variations in the fucosyltransferase 2 (FUT2), cubilin (CUBN), and transcobalamin-I (TCN1) genes. An altered vitamin B12 level is an important factor that disturbs the homeostasis of the folate metabolism pathway, which in turn can potentially...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24533076
DOI: 10.1371/journal.pone.0088332
PMCID: PMC3922769

Genes

CUBN
FUT2
TCN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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