Article
On the retention of gene duplicates prone to dominant deleterious mutations.
Theoretical population biology - 1 May 2014
Malaguti Giulia, Singh Param Priya, Isambert Hervé
Abstract excerpt
Recent studies have shown that gene families from different functional categories have been preferentially expanded either by small scale duplication (SSD) or by whole-genome duplication (WGD). In particular, gene families prone to dominant deleterious mutations and implicated in cancers and other genetic diseases in human have been greatly expanded through two rounds of WGD dating back from early vertebrates....
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