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Enhanced production of 2,3-butanediol by overexpressing acetolactate synthase and acetoin reductase in Klebsiella pneumoniae.

Biotechnology and applied biochemistry - 1 Jan 2000

Guo Xue-Wu, Zhang Yun-Hui, Cao Chun-Hong, Shen Tong, Wu Ming-Yue, Chen Ye-Fu, Zhang Cui-Ying, Xiao Dong-Guang

Abstract excerpt

Mutants with overexpression of α-acetolactate synthase (ALS), α-acetolactate decarboxylase, and acetoin reductase (AR), either individually or in combination, were constructed to improve 2,3-butanediol (2,3-BD) production in Klebsiella pneumoniae. The recombinant strains were characterized in terms of the enzyme activity, 2,3-BD yield, and expression levels. The recombinant K. pneumoniae strain (KG-rs) that...

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PMID: 24527770
DOI: 10.1002/bab.1217

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